Dr. Nicole Kretzer, MD PHD
Dr. Nicole Kretzer, MD PhD is a board-certified full spectrum gynecologist specializing in comprehensive gynecologic care. After completing her OB/GYN residency, she did three years of extra training in urogynecology and minimally invasive gynecologic surgery. Because she has never practiced obstetrics, she has been able to devote her entire career to complex gynecologic care. This background gives her a broad knowledge base and the ability to handle a wide range of issues including fibroids, endometriosis, pelvic pain, abnormal uterine bleeding, urinary symptoms, pelvic organ prolapse, and menopause. She also sees patients for routine gynecologic care including annual exams, pap smears, and contraception counseling.
Dr. Kretzer is highly skilled in in-office procedures, such as intrauterine device (IUD) placement, colposcopy, and endometrial biopsy. She is especially sensitive to ensuring patients are as comfortable as possible during procedures and has pioneered a comprehensive anesthesia regimen including numbing gel, injectable lidocaine, nitrous oxide (laughing gas), aroma therapy, and soothing music.
Dr. Kretzer is well-loved by patients and team members alike. She is a strong communicator, and loves taking the time to educate her patients about their bodies and treatment options so they can make informed decisions about their care. Reflecting this she has been voted a Seattle Met Top Doc by her peers, and is highly rated on Google. Her research background and PhD in immunology make her uniquely suited to make sure her patients understand the science behind their diagnoses. She hopes to one day return to the lab to develop an endometriosis vaccine.
Publications:
Bowman-Kirigin JA, Desai R, Saunders BT, Wang AZ, Schaettler MO, Liu CJ,Livingstone AJ, Kobayashi DK, Durai V, Kretzer NM, Zipfel GJ, Leuthardt EC, Osbun JW, Chicoine MR, Kim AH, Murphy KM, Johanns TM, Zinselmeyer BH, Dunn GP. The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain. Cancer Immunol Res. 2023 January; 11 (1): 20–37. PMID 36409838.
Lokken EM, Huebner EM, Taylor GG, Hendrickson S, Vanderhoeven J, Kachikis A, Coler B, Walker CL, Sheng JS, al-Haddad BJS, McCartney SA, Kretzer NM, Resnick R, Barnhart N, Schulte V, Bergam B, Ma KK, Albright C, Larios V, Kelly L, Larios V, Emhoff S, Rah J, Retzlaff K, Thomas C, Paek BW, Hsu RJ, Erickson A, Chang A, Mitchell T, Hwang JK, Erickson S, Delaney S, Archabald K, Kline CR, LaCourse SM, Adams Waldorf KM. Disease severity, pregnancy outcomes, and maternal deaths among pregnant patients with Severe Acute Respiratory Syndrome Coronavirus 2 infection in Washington state. Am J Obstet Gynecol. 2021 July; 225(1): 77.e1-77e14. PMID: 33515516.
Lokken EM, Taylor GG, Huebner EM, Vanderhoeven J, Hendrickson S, Coler B, Sheng JS, Walker CL, McCartney SA, Kretzer NM, Resnick R, Kachikis A, Barnhart N, Schulte V, Bergam B, Ma KK, Albright C, Larios V, Kelley L, Emhoff S, Rah J, Retzlaff K, Thomas C, Paek BW, Hsu RJ, Erickson A, Chang A, Mitchell T, Hwang JK, Gourley R, Erickson S, Delaney S, Kline CR, Archibald K, Blain M, LaCourse SM, Adams Waldorf KM. Higher Severe Acute Respiratory Syndrome Coronavirus 2 infection rate in pregnant patients. Am J Obstet Gynecol. 2021 July; 225(1): 75.e1-75.e16. PMID 33607103.
LaCourse SM, Kachikis A, Blain M, Simmons LE, Mays JA, Pattison AD, Salerno CC, McCartney SA, Kretzer NM, Resnick R, Shay RL, Savitsky LM, Curtin AC, Huebner EM, Ma KK, Delaney S, Delgado C, Schippers A, Munson J, Pottinger PS, Cohen S, Neme S, Bourassa L, Bryan A, Greninger A, Jerome KR, Roxby AC, Lokken E, Cheng E, Adams Waldorf KM, Hitti J. Low prevalence of Severe Acute Respiratory Syndrome Coronavirus 2 among pregnant and postpartum patients with universal screening in Seattle, Washington. Clin Infect Dis. 2021 Mar 1; 72(5): 869-72. PMID 32472688.
Lokken EM, Walker CL, Delaney S, Kachikis A, Kretzer NM, Erickson A, Resnick R, Vanderhoeven J, Hwang JK, Barnhart N, Rah J, McCartney SA, Ma KK, Huebner EM, Thomas C, Sheng JS, Paek BW, Retzlaff K, Kline CR, Munson J, Blain M, LaCourse SM, Deutsch G, Adams Waldorf KM. Clinical characteristics of 46 pregnant women with a Severe Acute Respiratory Syndrome Coronavirus 2 infection in Washington state. Am J Obstet Gynecol. 2020 Dec; 223(6): 911.e1-911.e14. PMID 32439389.
Weed S, Armistead B, Coleman M, Liggit HD, Johnson B, Tsai J, Beyer RP, Bammler TK, Kretzer NM, Parker E, Vanderhoeven JP, Bierle CJ, Rajagopal L, Adams Waldorf KM. MicroRNA signature of epithelial-mesenchymal transition in Group B Streptococcal infection of the placental chorioamniotic membranes. J Infect Dis. 2020 Oct 13l; 222(10): 1713-22. PMID: 32453818.
Tussiwand R, Behnke MS, Kretzer NM, Grajales-Reyes GE, Murphy TL, Schreiber RD, Murphy KM, Sibley LD. An important role for CD4+ T cells in adaptive immunity to Toxoplasma gondii in mice lacking the transcription factor Batf3. mSphere. 2020 Jul 15; 5(4):e00634-20. PMID 32669460.
Coleman M, Orvis A, Wu T, Dacanay M, Merillat S, Ogle J, Baldessari A, Kretzer NM, Munson J, Boros-Rausch AJ, Shynlova O, Lye S, Rajagopal L & Adams-Waldorf KM. A broad spectrum chemokine inhibitor prevents preterm labor but not microbial invasion of the amniotic cavity or neonatal morbidity in a non-human primate model. Front Immunol.2020 Apr 30; 11(770). eCollection 2020. PMID 32425945.
Theisen DJ, Ferris ST, Briseño CG, Kretzer NM, Iwata A, Murphy KM & Murphy TL.Batf3-dependent genes control tumor rejection induced by dendritic cells independently of cross-presentation. Cancer Immunology Research. 2019 Jan; 7(1): 29-39. PMID 30482745.
Brähler S, Zinselmeyer BH, Raju S, Nitschke M, Suleiman H, Saunders BT, Johnson MW, Böhner AMC, Viehmann SF, Theisen DJ, Kretzer NM, Briseño CG, Zaitsev K, Ornatsky O, Chang Q, Carrero JA, Kopp JB, Artyomov MN, Kurts C, Murphy KM, Miner JH & Shaw AS. Opposing roles of dendritic cell subsets in experimental GN. J Am Soc Nephrol. 2018 Jan; 29(1): 138-154. PMID 29217759.
Wu X, Briseño CG, Grajales-Reyes GE, Haldar M, Iwata A, Kretzer NM, KC W, Tussiwand R, Higashi Y, Murphy TL & Murphy KM. Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate. Proc Natl Acad Sci USA. 2016 Dec 20; 113(51): 14775-80. PMID 27930303.
Kretzer NM, Theisen DJ, Tussiwand R, Briseño CG, Grajales-Reyes GE, Wu X, Durai V, Albring JC, Bagadia P, Murphy TL & Murphy KM. Rab43 facilitates crosspresentation of cell-associated antigens by CD8alpha(+) dendritic cells. J Exp Med. 2016 Dec 12; 213(13): 2871-83. PMID 27899443.
Briseño CG, Haldar M, Kretzer NM, Wu X, Theisen DJ, KC W, Durai V, GrajalesReyes GE, Iwata A, Bagadia P, Murphy TL & Murphy KM. Distinct transcriptional programs control cross-priming in classical- and monocyte-derived dendritic cells. Cell Rep. 2016 June 14; 15(11): 2462-74. PMID 27264183.
Murphy TL, Grajales-Reyes GE, Wu X, Tussiwand R, Briseño CG, Iwata A, Kretzer NM, Durai V & Murphy KM. Transcriptional control of dendritic cell development.Annu Rev Immunol. 2016 May 20; 34: 93-119. PMID 26735697.
Grajales-Reyes GE, Iwata A, Albring JC, Wu X, Tussiwand R, KC W, Kretzer NM, Briseño CG, Durai V, Bagadia P, Haldar M, Schönheit J, Rosenbauer F, Murphy TL & Murphy KM. Batf3 maintains autoactivation of Irf8 for commitment of a CD8a(+) conventional DC clonogenic progenitor. Nat Immunol. 2015 Jul; 16(7): 708-17. PMID 26054719.
Tussiwand R, Everts B, Grajales-Reyes GE, Kretzer NM, Iwata A, Bagaitkar J, Wu X, Wong R, Anderson DA, Murphy TL, Pearce EJ & Murphy KM. Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity. 2015 May 19; 42(5): 916-28. PMID 25992862.
Haldar M, Kohyama M, So AY, KC W, Wu X, Briseño CG, Satpathy AT, Kretzer NM, Arase H, Rajasekaran NS, Wang L, Egawa T, Igarashi K, Baltimore D, Murphy TL & Murphy KM. Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 2014 Mar 13; 156(6): 1223-34. PMID 24630724.
KC W, Satpathy AT, Rapaport AS, Briseño CG, Wu X, Albring JC, Russler-Germain EV, Kretzer NM, Durai V, Persaud SP, Edelson BT, Loschko J, Cella M, Allen PM, Nussenzweig MC, Colonna M, Sleckman BP, Murphy TL & Murphy KM. L-Mycexpression by dendritic cells is required for optimal T-cell priming. Nature. 2014 Mar 13; 507(7491): 243-7. PMID 24509714.
Tussiwand R, Lee WL, Murphy TL, Mashayekhi M, KC W, Albring JC, Satpathy AT, Rotondo JA, Edelson BT, Kretzer NM, Wu X, Weiss LA, Glasmacher E, Li P, Liao W, Behnke M, Lam SS, Aurthur CT, Leonard WJ, Singh H, Stallings CL, Sibley LD, Schreiber RD & Murphy KM. Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature. 2012 Oct 25; 490(7421): 502-7. PMID 22992524.
Satpathy AT, KC W, Albring JC, Edelson BT, Kretzer NM, Bhattacharya D, Murphy TL & Murphy KM. Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med. 2012 Jun 4; 209(6): 1135-52. PMID 22615127.
Kretzer NM, Cherian MT, Mao C, Aninye IO, Reynolds PD, Schiff R, Hergenrother PJ, Nordeen SK, Wilson EM & Shapiro DJ. A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor {alpha}. J Biol Chem. 2010 Dec 31; 285(53): 41863-73. PMID 21041310.
Mao C, Patterson NM, Cherian MT, Aninye IO, Zhang C, Montoya JB, Cheng J, Putt KS, Hergenrother PJ, Wilson EM, Nardulli AM, Nordeen SK & Shapiro DJ. A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. J Biol Chem. 2008 May 9; 283(19): 12819-30. PMID: 18337247
Jiang X, Patterson NM, Ling Y, Xie J, Helferich WG & Shapiro DJ. Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells. Endocrinology. 2008 Nov; 149(11): 5366-73. PMID 18669594.
